Blar i forfatter "Sovershaev, Timofey"

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    • Antibody-based targeting of alternatively spliced tissue factor: A new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma 

      Unruh, Dusten; Ünlü, Betü; Lewis, Clayton S.; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A.; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J.; Ramchandani, Divya; Weber, Georg F.; Rak, Janusz W.; Wolberg, Alisa S.; Mackman, Nigel; Versteeg, Henri H.; Bogdanov, Vladimir Y. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promotes tumor growth, metastatic spread, and monocyte recruitment to the stroma. In this study, we determined ...

    • Bone morphogenetic proteins: Novel mediators of atherothrombosis 

      Sovershaev, Timofey (Doctoral thesis; Doktorgradsavhandling, 2016-12-08)
      Atherosclerosis is a major cause of morbidity and mortality in western world. Bone morphogenetic proteins are secreted regulatory proteins that regulate various processes throughout human body. Recent studies indicate their presence in atherosclerotic plaques and emerging role in plaque development. Since monocytes are the key effector cells in atherosclerosis, the aim of this thesis was to investigate ...

    • Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis 

      Jamaly, Simin; Ramberg, Cathrine; Olsen, Randi; Latysheva, Nadezhda; Webster, Paul; Sovershaev, Timofey; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)
      Optimal pre-analytical handling is essential for valid measurements of plasma concentration and size distribution of extracellular vesicles (EVs). We investigated the impact of plasma preparation, various anticoagulants (Citrate, EDTA, CTAD, Heparin), and fasting status on concentration and size distribution of EVs measured by Nanoparticle Tracking Analysis (NTA). Blood was drawn from 10 healthy ...

    • A modified clot-based assay to measure negatively charged procoagulant phospholipids 

      Ramberg, Cathrine; Jamaly, Simin; Latysheva, Nadezhda; Wilsgård, line; Sovershaev, Timofey; Snir, Omri; Hansen, Jesper (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-29)
      Growing evidence supports a role for extracellular vesicles (EVs) in haemostasis and thrombosis due to exposure of negatively charged procoagulant phospholipids (PPL). Current commercial PPL-dependent clotting assays use chemically phospholipid depleted plasma to measure PPL activity. The purpose of our study was to modify the PPL assay by substituting the chemically phospholipid depleted plasma ...

    • Plasma procoagulant phospholipid clotting time and venous thromboembolism risk 

      Ramberg, Cathrine; Wilsgård, line; Latysheva, Nadezhda; Brækkan, Sigrid Kufaas; Hindberg, Kristian; Sovershaev, Timofey; Snir, Omri; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
      Background - Negatively charged procoagulant phospholipids, phosphatidylserine (PS) in particular, are vital to coagulation and expressed on the surface membrane of extracellular vesicles. No previous study has investigated the association between plasma procoagulant phospholipid clotting time (PPL<sub>CT</sub>) and future risk of venous thromboembolism (VTE).<p> <p>Objectives - To investigate the ...